Table 4.

Univariate and multivariate analysis of local recurrence-free and distant recurrence-free survival

	Local recurrence-free survival				Distant recurrence-free survival
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age, ≥ 45 v. < 45	1.03 (0.65–1.63)	0.888			1.36 (0.91–2.01)	0.132
Sex, female v. male	0.59 (0.38–0.91)	0.018	0.65 (0.30–1.39)	0.269	0.63 (0.42–0.93)	0.022	0.83 (0.50–1.35)	0.450
Subtype
Sporadic v. NF1-associated	0.85 (0.54–1.33)	0.463			0.85 (0.58–1.25)	0.413
Sporadic v. RT-associated	0.42 (0.23–0.82)	0.010	0.36 (0.12–1.79)	0.082	1.17 (0.54–2.51)	0.686
Histology, other a v. MPNST	0.86 (0.43–1.71)	0.658			0.46 (0.21–1.00)	0.050	0.62 (0.26–1.44)	0.266
Size, ≥ 10 cm v. < 10 cm	2.26 (1.23–4.16)	0.008	2.09 (0.98–4.49)	0.056	2.06 (1.26–3.36)	0.004	1.76 (1.04–2.97)	0.034
Location, trunk v. other b	2.01 (1.29–3.14)	0.002	1.43 (0.67–3.04)	0.353	1.06 (0.72–1.57)	0.749
Depth, deep v. superficial	3.25 (0.79–13.2)	0.100			9.39 (1.31–67.5)	0.026	1.79 (0.93–15.3)	0.566
Chemotherapy, yes v. no	0.90 (0.57–1.38)	0.599			1.51 (1.02–2.22)	0.037	1.15 (0.68–1.94)	0.596
Radiation therapy, yes v. no	0.64 (0.41–0.98)	0.040	0.84 (0.41–1.68)	0.619	0.84 (0.56–1.24)	0.365
Margins, positive v. negative	3.62 (2.18–6.04)	<0.001	3.13 (1.56–6.25)	<0.001	0.97 (0.58–1.62)	0.631

Abbreviations: P, P Value. Bold indicates statistical significance p < 0.05.

^aEpithelioid type or triton tumor

^bextremity or head/neck