Table 5.

Univariate and multivariate predictors of adverse local recurrence-free survival in patients with sporadic or NF1-asscociated MPNST that presented to our institution with primary disease (n = 128)^a

Variable	Univariate		Multivariate
	HR (95% CI)	P Value	HR (95% CI)	P Value
Age, ≥ 45 v. <45	0.85 (0.38–1.91)	0.691
Sex, female v. male	0.37 (0.17–0.82)	0.014	0.34 (0.12–0.94)	0.039
Subtype, sporadic v. NF1-associated	0.40 (0.17–0.84)	0.036	0.38 (0.13–1.15)	0.385
Histology, other b v. MPNST	0.67 (0.34–2.32)	0.805
Size, ≥ 10 cm v. <10 cm	2.35 (0.92–5.99)	0.074
Location, trunk v. other c	2.06 (0.99–4.27)	0.051	1.17 (0.48–2.84)	0.721
Chemotherapy, yes (n = 59) v. no (n = 69)	1.06 (0.52–2.19)	0.862
Radiation, yes (n = 69) v. no (n = 59)	0.49 (0.24–1.02)	0.058	0.49 (0.20–1.23)	0.130
Margins, positive v. negative	5.08 (2.27–11.4)	<0.001	3.90 (1.69–8.97)	0.001

Bold indicates statistical significance p < 0.05

^aPatients with localized primary sporadic or NF1-associated MPNST who underwent R0 or R1 resection

^bEpithelioid type or triton tumor

^cExtremity or head/neck