Table 6.

Univariate and multivariate predictors of adverse disease-specific survival

	Univariate		Multivariate
	HR (95% CI)	P Value	HR (95% CI)	P Value
Age, ≥ 45 v. < 45	1.18 (0.77–1.81)	0.438
Sex, female v. male	0.66 (0.43–0.99)	0.047	1.53 (0.81–2.91)	0.194
Subtype
Sporadic v. NF1-associated	0.59 (0.39–0.91)	0.016	1.00 (0.48–2.06)	0.997
Sporadic v. RT-associated	0.52 (0.26–1.08)	0.058	1.35 (0.48–3.75)	0.568
Histology, epithelioid/Triton v. MPNST	0.59 (0.27–1.29)	0.192
Size, ≥ 10 cm v. < 10 cm	3.14 (1.88–5.23)	<0.001	1.78 (0.91–3.84)	0.092
Location, trunk v. extremity or head/neck	1.56 (1.07–2.27)	0.021	1.92 (1.03–3.58)	0.039
Depth, deep v. superficial	2.37 (0.75–7.52)	0.141
Chemotherapy, yes v. no	1.68 (1.12–2.53)	0.012	1.46 (0.76–2.08)	0.261
Radiation therapy, yes v. no	0.64 (0.43–0.97)	0.035	0.81 (0.46–1.47)	0.501
Margins, positive v. negative	2.14 (1.32–3.45)	0.002	2.41 (1.19–4.84)	0.014
Local recurrence, yes v. no	2.46 (1.63–3.72)	<0.001	1.95 (0.96–3.89)	0.059
Distant recurrence, yes v. no	4.61 (2.83–7.52)	<0.001	10.7 (4.89–23.5)	<0.001

Bold indicates statistical significance p < 0.05.