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. Author manuscript; available in PMC: 2017 Jan 2.
Published in final edited form as: J Neurosurg. 2016 Apr 1;126(1):319–329. doi: 10.3171/2015.12.JNS152443

Table 7.

MPNST: a review of select recent single-institution retrospective series

Authors & Year No.
Patients
5 year
survival
Adverse prognostic features Therapy
Benefit

NF1 RAS Location Size Positive
Margins
RT CT
Present series 289 52%a T NS T (trunk) S (≥ 10 cm) S NS NS
LaFemina et al., 2013 105 - NS S NS S (larger) S - -
Fan et al., 2013 146 57% b NS - NS NS NS NS NS
Stucky et al., 2011 175 60% a T - S (trunk) S (≥ 5cm) NS NS NS
Zou et al., 2009 140 39% a NS NS NS S (≥ 10 cm) NS NS NS
Porter et al., 2008 123 51% b S - NS S (> 200 ml) NS NS NS
Anghileri et al., 2006 205 40% a NS - S (trunk, HN) S (larger) S S NS

Abbreviations: CT, chemotherapy; HN, head/neck; NF1, neurofibromatosis type1-associated MPNST; NS, not statistically significant; RAS, radiation-associated MPNST; RT, radiation therapy ; S, statistically significant; T, trend

a

Disease-specific survival

b

Overall survival

c

Tri-site series for a single-institution