Table 2.

Odds ratio for high compared to low lifetime CVD risk profile for each standard deviation increase in alpha diversity estimates among Bogalusa microbiome study participants (N=112).

	Model 1*		Model 2†		Model 3‡
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Richness
Observed OTUs	0.62 (0.39, 0.99)	0.04	0.54 (0.28, 1.01)	0.06	0.54 (0.27, 1.10)	0.09
Chao 1	0.61 (0.38, 0.98)	0.04	0.54 (0.29, 1.01)	0.05	0.54 (0.27, 1.07)	0.08
ACE	0.63 (0.39, 0.99)	0.05	0.53 (0.28, 1.01)	0.05	0.55 (0.27, 1.10)	0.09
Richness and Evenness
Shannon index	0.77 (0.49, 1.20)	0.25	0.57 (0.29, 1.13)	0.11	0.54 (0.26, 1.16)	0.11
Simpson’s index	0.86 (0.56, 1.34)	0.51	0.62 (0.32, 1.22)	0.17	0.62 (0.30, 1.28)	0.19
Inverse Simpson index	0.82 (0.52, 1.28)	0.37	0.65 (0.33, 1.32)	0.24	0.61 (0.28, 1.30)	0.20

ACE=Abundance-based coverage estimator; CI=Confidence interval; OR=Odds ratio; OUT=Operational taxonomic unit.

^*Adjusted for age, gender and race.

^†Adjusted for age, gender, race and body mass index.

^‡Adjusted for age, gender, race, body mass index, dietary protein intake^§, animal fat intake^§, dietary fiber intake^§, and total energy intake.

^§Adjusted for total energy intake using the residual method.