. Author manuscript; available in PMC: 2017 Oct 25.

Published in final edited form as: Chem Biol Interact. 2016 Aug 16;258:21–29. doi: 10.1016/j.cbi.2016.08.010

Table 1.

Effect of epigenetic inhibitors on chemotherapeutic-induced toxicity in prostate cancer cells^a

			+ 5-Aza^b		+ CBZ		+ TSA
	LNCaP	PC-3	LNCaP	PC-3	LNCaP	PC-3	LNCaP	PC-3
Docetaxel	✓^c	✓	+	-	-	-	+	-
Cisplatin	✓	✓	-	-	-	-	+	-
CFZ	-	✓	-	+	-	-	-	-

Cells were exposed to docetaxel, cisplatin or carfilzomib (CFZ) for 48 hr, after which toxicity was assessed using MTT staining.

Cells were pretreated for 30 min with 5-Aza = 5-azacytidine, CBZ = carbamezapine or TSA = trichostatin A prior to chemotherapeutic exposure.

✓ indicates that the given chemotherapeutic was toxic, while - indicates no significant effect and + indicates increased toxicity in the presence of the specified epigenetic inhibitor.