Treatment of obese type 2 diabetes mellitus (T2DM) patients with dapagliflozin 5 mg once daily for 12 weeks significantly improved HbA1c levels and body weight to the same level as previous reports.

Although ketone bodies increased significantly, high-sensitivity C-reactive protein significantly decreased, while adiponectin significantly increased.

During the meal tolerance test, blood glucose Δ area under the curve from time zero to 2 h (AUC2) reduced significantly, but glucagon ΔAUC2 increased, while immunoreactive insulin did not differ.