Table 3.
Complications in the course of the disease
| 2003–2015 | 1984–2002 | P value | |
|---|---|---|---|
| Intracranial complicationsa | 52.7 % | 74.7 % | 0.010 |
| Brain edema | 14.5 % | 28.7 % | 0.066 |
| Epileptic seizures | 14.5 % | 27.6 % | 0.098 |
| Cerebral ischemia | 12.7 % | 18.4 % | 0.485 |
| Hydrocepahlus | 10.9 %b | 16.1 % | 0.464 |
| Sinus thrombosis | 7.3 % | 9.1 % | 0.766 |
| Intracranial bleeding | 3.6 % | 9.1 % | 0.316 |
| Cerebral vasculopthy | 40 % | not assessed | |
| Hearing loss | 32.7 % | 19.5 % | 0.23 |
| Systemic complications | 34.5 % | 48.3 % | 0.12 |
| Pneumonia | 21.8 % | 21.8 % | 1.0 |
| Sepsis | 16.4 % | 31.0 % | 0.074 |
| Renal failure | 5.5 % | 11.5 % | 0.371 |
| Disseminated intravasal coagulation | 3.6 % | 23 % | 0.002 |
aNot including cerebral vasculopathy, as this was not assessed in the previous study period. See main text for details. bFive of six patients required an external ventricular drain