Table 3.
Pharmacokinetic parameter data in whole blood and plasma
| Analyte | Cmax (ng Eq/mL) | Tmax (hours) | AUC0−∞ (ng Eq·h/mL) | t1/2 (hours) | Vz/F (L) | CL/F (L/h) |
|---|---|---|---|---|---|---|
| Radioactivity in plasma | 11.66±3.54 (11.28) | 1.83±1.13 (1.62) | 137.31±56.10 (130.41) | 10.9±2.54 (10.6) | NC | NC |
| Radioactivity in whole blood | 9.25±2.14 (9.06) | 2.17±1.03 (1.98) | 101.96±41.58 (95.98) | 6.96±1.51 (6.82) | NC | NC |
| Revexepride in plasma | 4.64±0.89 (4.58) | 1.75±1.17 (1.51) | 43.48±13.80 (41.76) | 11.0±2.38 (10.8) | 828±118 | 49.8±15.2 |
Note: Values are arithmetic mean ± standard deviation (geometric mean).
Abbreviations: AUC0−∞, area under the concentration–time curve from time 0 extrapolated to infinity; CL/F, plasma clearance; Cmax, maximum concentration; Eq, equivalent; NC, not calculated; t1/2, mean elimination half-life; Tmax, time to Cmax; Vz/F, volume of distribution.