Table 4.

Summary of “peripapillary” RNFL findings on optical coherence tomography in studies included in the meta-analysis and the present study

Authors	Year	Location	# MCI	Mean age, MCI (±SD)	Average MMSE MCI	# Control	Mean age, control (±SD)	Grade	Total RNFL		Superior		Inferior		Nasal		Temporal
									MCI	Control	MCI	Control	MCI	Control	MCI	Control	MCI	Control
Ascaso et al.	2014	Spain	21	72.1 ± 8.7	19.3	41	72.9 ± 7.9	Fair	87.3 ± 7.22∗	102.7 ± 6.89∗	104.0 ± 15.74∗	128.2 ± 14.4∗	111.1 ± 19.0∗	132.7 ± 13.25∗	65.9 ± 17.6	75.9 ± 13.3	68.5 ± 16.5∗	74.9 ± 13.5∗
Gao et al.	2014	China	26	73.4 ± 1.5	25.8	21	72.1 ± 1.0	Good	92.38 ± 1.94	98.60 ± 1.67	112.12 ± 3.31	122.25 ± 2.95	123.87 ± 3.36	127.59 ± 2.72	68.54 ± 1.52	69.71 ± 1.55	66.56 ± 2.44∗	74.60 ± 2.11∗
Kesler et al.	2011	Israel	24	71.0 ± 10.0	28.1	24	70.9 ± 9.2	Fair	85.8 ± 10.0∗	94.3 ± 11.3∗	101.3 ± 15.2	110.0 ± 16.7	111.9 ± 16.1∗	127.0 ± 15.5∗	65.9 ± 15.1	76.4 ± 21.8	64.2 ± 13.9	67.8 ± 15.1
Shen et al.	2014	China	23	74.4 ± 3.2	22.2	52	74.1 ± 2.6	Good	82.6 ± 10.5	85.6 ± 10.2	101.8 ± 16.8	104.7 ± 15.4	104.5 ± 17.6	109.3 ± 21.3	61.5 ± 8.1	64.8 ± 8.4	62.7 ± 12.2	65.5 ± 10.1
Liu et al.	2015	China	26	70.2 ± 6.5	—	39	69.7 ± 7.8	Fair	95.4 ± 17.11	100.12 ± 15.0	115.14 ± 13.5∗	119.1 ± 15.3∗	120.23 ± 18.0	125.7 ± 11.2	74.8 ± 12.36	79.9 ± 12.9	63.8 ± 13.2	67.34 ± 15.3
Cheung et al.	2015	Singapore	41	70.4 ± 10.2	—	123	65.7 ± 3.8	Fair	87.3 ± 7.22	102.7 ± 6.89	104.0 ± 15.74	128.2 ± 14.4	111.1 ± 19.0	132.7 ± 13.25	65.9 ± 17.6	75.9 ± 13.3	68.5 ± 16.5	74.9 ± 13.5
Knoll et al.	Present study	USA	17	74.5 ± 8.9	27.3	17	74.8 ± 8.3	Good	90.2 ± 12.2	91.0 ± 10.5	106.8 ± 18.2	106.2 ± 18.8	120.0 ± 18.6	119.2 ± 17.4	75.3 ± 19.5	68.2 ± 21.6	65.1 ± 15.1	67.8 ± 16.2

Abbreviations: MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; RNFL, retinal nerve fiber layer; SD, standard deviation.

^∗Study found significant difference between MCI and controls in this quadrant.