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. 2016 Oct 3;2:16025. doi: 10.1038/cddiscovery.2016.25

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) A flow cytometric analysis concerning the expression of CD8⁺Ki67⁺ cells in T-cell cultures undergone multiple in vitro stimulation with IRIV and derived from the PBMCs of normal donors (ND) or mNSCLC patients isolated at the baseline () and after four treatment courses () with the mPE doublet alone or combined with bevacizumab (mPEBev). Further panels describe the ELISA dosage of T_h1 (IFNɣ, TNFα ) and T_h2 (IL4 and IL10) cytokines in the supernatant of T-cell cultures in vitro stimulated with SEB (b), IRIV (c) and TSPP (d), and derived from the PBMCs of normal donors (ND) or mNSCLC patients and isolated at the baseline () or after four treatment courses () with the doublet alone (mPE) or combined with bevacizumab (mPEBev). Results are expressed as fold induction relative to baseline indicated as 1 (±S.E.). Asterisk represents statistical significance to the correspondent baseline values (*P<0.05).

Inline graphic — (a) A flow cytometric analysis concerning the expression of CD8⁺Ki67⁺ cells in T-cell cultures undergone multiple in vitro stimulation with IRIV and derived from the PBMCs of normal donors (ND) or mNSCLC patients isolated at the baseline () and after four treatment courses () with the mPE doublet alone or combined with bevacizumab (mPEBev). Further panels describe the ELISA dosage of T_h1 (IFNɣ, TNFα ) and T_h2 (IL4 and IL10) cytokines in the supernatant of T-cell cultures in vitro stimulated with SEB (b), IRIV (c) and TSPP (d), and derived from the PBMCs of normal donors (ND) or mNSCLC patients and isolated at the baseline () or after four treatment courses () with the doublet alone (mPE) or combined with bevacizumab (mPEBev). Results are expressed as fold induction relative to baseline indicated as 1 (±S.E.). Asterisk represents statistical significance to the correspondent baseline values (*P<0.05).