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. 2016 Sep 18;2016:2543070. doi: 10.1155/2016/2543070

Figure 4.

Figure 4

Anti-TNF therapy downregulates PLD2 expression. (a) Patients with A-CD (n = 17) were treated with anti-TNF mAb (IFX, 5 mg/kg) as indicated. Intestinal mucosal biopsies were collected before and at week 12 after the first infusion. Expression of PLD2 mRNA in intestinal mucosa was detected by qRT-PCR. ∗∗ p < 0.01 versus that before IFX treatment. ((b) and (c)) Fresh colonic biopsies were harvested from inflamed mucosa in patients with active CD ((b) n = 10) or active UC ((c) n = 10) and cultured in vitro with IFX or control human IgG (HIg) (50 μg/mL) for 24 h. Expression of PLD2 mRNA was detected by qRT-PCR. ∗∗ p < 0.01 and ∗∗∗ p < 0.001 versus controls.