. 2016 Jul 8;36(10):1686–1694. doi: 10.1177/0271678X16658302

Table 1.

Study characteristics.

Author	Year	Drug	Species	Sex	Anesthetic	Route of delivery	Outcome measure(s)	Dose (mg/kg)	Time of admin (min)	Time of assessment (h)	Ischemia type (P/T)	N (C)	N (Rx)
Rajanikant	2007	Carnosine	C57BL/6 mice	M	Isoflurane	IP	Infarct volume	100	−30	24	P	10	10
								500	−30	24	P	10	10
								1000	30	24	P	10	10
								1000	−30	24	P	10	10
								2500	240	24	P	7	7
								2500	120	24	P	7	7
Min	2008	Carnosine	C57BL/6 mice	NR	Halothane	IP	Infarct volume and neurobehavioral score	1000	−30	24	P	7	7
								1000	−30	72	P	7	7
								1000	−30	168	P	7	7
Shen	2010	Carnosine	C57BL/6 Mice	M	Sodium pentobarbital	IP	Infract volume and neurobehavioral score	250	−30	24	P	5	5
								500	−30	24	P	5	5
								750	−30	24	P	5	5
Bae	2013⁸	Carnosine	Sprague-Dawley rats	M	Isoflurane	IV	Infarct volume and Neurobehavioral score	500	180	24	T (180)	14	15
								1000	180	24	T (180)	14	15
								2000	180	24	T (180)	14	15
								1000	540	24	T (540)	7	13
								1000	720	24	P	13	15
								1000	540	24	P	14	15
								1000	360	24	T (360)	13	14
								1000	360	24	P	13	15
								1000	180	24	P	14	15
Bae	2013¹¹	Carnosine	Sprague-Dawley rats	M	Isoflurane	IV	Infarct volume	1000	−30	24	P	10	10
Wang	2013	Carnosine	Sprague-Dawley rats	M	Isoflurane	IP	Infarct volume and neurobehavioral score	500	−30	72	P	6	6
								750	−30	72	P	6	6
								1000	−30	72	P	6	6
Park	2014	Carnosine	Rat (strain not given)	NR	Isoflurane	IP	Infarct volume	100	−30	2	P	5	5
								250	−30	2	P	5	5
								500	−30	2	P	5	5
Baek	2014	Carnosine	Sprague-Dawley rats	M	Isoflurane	Lateral tail vein	Infarct volume	1000	360	24	P	14	16

IV: intravenous; IP: intraperitoneal; NR: not reported, number after T in ischemia type columns denotes the duration of transient ischemia; M: males; N: number; C: control; Rx: treatment; P: permanent; T: transient.