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Small HCC (⩽3 cm) had higher cccDNA and HBV DNA copy number when compared with large HCC (>3 cm). Box plot showing cccDNA copy per cell (A) or HBV DNA copy per cell (B) within the tumour (filled bars) or non-neoplastic liver (open bars) of patients with small HCC (⩽3 cm) or large HCC (>3 cm).
