Table 1. Comparison of HBV DNA viral load and replicative activity within tumour and paired non-neoplastic liver (n=99 pairs).
| Tumour | Non-neoplastic liver | P-value | |
|---|---|---|---|
|
HBV DNA (copies per cell) | |||
| Detectable | 86/99 (86%) | 96/99 (96%) | 0.02 |
| Median (range) | 0.04 (0–4441.2) | 0.07 (0–17.5) | 0.7 |
|
cccDNA (copies per cell) | |||
| Detectable | 61/99 (62%) | 93/99 (94%) | <0.001 |
| Median (range) | 0.00004 (0–2.7) | 0.008 (0–0.8) | 0.03 |
|
Replicative activity cccDNA/HBV DNA ratio | |||
| Median (range) | 0.008 (0–24.6) | 0.1 (0–9.7) | 0.002 |
Abbreviations: cccDNA=covalently closed circular DNA; HBV=hepatitis B virus. P<0.05 were indicated in bold.