Table 1. Clinico-pathological variables and SULF2 scores in patients with PDAC.
| Patient characteristics | Number |
|---|---|
| Total | 93 |
| Age (years, median) | 65.3 |
| Sex (female:male) | 40:53 |
| Tumour stage | |
| T1: tumour within pancreas <2 cm | 3 |
| T2: tumour within pancreas >2 cm | 19 |
| T3: local invasion | 70 |
| T4: distant or large vessel invasion | 1 |
| Resection (R0:R1) | 28:65 |
| Lymph nodes (−ve:+ve) | 8:85 |
| Tumour grade | |
| Well differentiated | 1 |
| Moderately differentiated | 31 |
| Poorly differentiated | 61 |
| Vascular invasion (no:yes) | 16:77 |
| Perineural invasion (no:yes) | 2:91 |
| Lymphatic invasion (no:yes) | 33:60 |
| Lymph nodes positive | 8:85 |
| Tumour site | |
| Head of pancreas/neck/uncinate | 89/2/1 |
| Neck and body | 1 |
| Adjuvant chemotherapy | |
| None | 47 |
| 5FU regime | 36 |
| Gemcitabine | 6 |
| Other (defined in text) | 4 |
| Palliative second-line chemotherapy | 32/56 |
| Survival (median months) | 16.5 |
|
SULF2 scoring | |
| Percentage SULF2-positive tumour cells | |
| 0=0% | 3 |
| 1=1–25% | 34 |
| 2=26–50% | 17 |
| 3=51–75% | 17 |
| 4=75–100% | 22 |
| SULF2 staining intensity | |
| 0=None | 3 |
| 1=Weak | 15 |
| 2=Moderate | 38 |
| 3=Strong | 37 |
| SULF2 combined score | |
| 0 | 3 |
| 1 | 0 |
| 2 | 9 |
| 3 | 8 |
| 4 | 35 |
| 5 | 13 |
| 6 | 13 |
| 7 | 12 |
| SULF2 tumour stroma | |
| None | 29 |
| Focal | 54 |
| Marked | 10 |
| SULF2 stroma outside | |
| None | 17 |
| Focal | 48 |
| Marked | 28 |
Abbreviations: R=resection margins; R0=negative resection margins; R1=microscopic tumour infiltration (that is, tumour cells present within 1 mm of the resection margin); SULF=sulfatase.