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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: Cell. 2016 Aug 25;166(5):1269–1281.e19. doi: 10.1016/j.cell.2016.07.049

Figure 7. A model of enhancer-cluster coordinated GC-inducible enhancer activation.

Figure 7

Prior to hormone exposure, AP-1 binds to the genome. AP-1 bound sites are in domains of increased chromatin accessibility that are enriched for H3K27ac, H3K4me1 and P300. After hormone exposure, GR binds directly to the genome in regions of less accessible chromatin. GR interacts with distal AP-1 bound sites within the same CTCF-defined topological domain. The epigenome of the direct GBSs is remodeled, becoming enriched for H3K27ac, H3K4me1 and increased in chromatin accessibility. Direct GBSs confer GC-inducible enhancer function, while AP-1 bound interacting sites modulate the expression output of direct GBSs.