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. 1993 Dec;77(12):795–798. doi: 10.1136/bjo.77.12.795

Cancer-associated retinopathy with retinal phlebitis.

Y Ohnishi 1, S Ohara 1, T Sakamoto 1, T Kohno 1, F Nakao 1
PMCID: PMC504659  PMID: 8110675

Abstract

A 50-year-old man with cancer-associated retinopathy was investigated using light and electron microscopy, immunofluorescence studies, and western blotting. He had visual disturbance, ring-like scotoma, and night blindness bilaterally. There were narrowed retinal arterioles and dilated retinal venules. Oral corticosteroid therapy had positive effects. Immunostaining using the patient's serum revealed a positive reaction in the ganglion cell layer of normal retina. Western blotting showed that the patient's serum antibody reacted with normal retinal proteins of 24 and 48 kDa. Multiple metastases were evident at autopsy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchanan T. A., Gardiner T. A., Archer D. B. An ultrastructural study of retinal photoreceptor degeneration associated with bronchial carcinoma. Am J Ophthalmol. 1984 Mar;97(3):277–287. doi: 10.1016/0002-9394(84)90623-8. [DOI] [PubMed] [Google Scholar]
  2. Grunwald G. B., Klein R., Simmonds M. A., Kornguth S. E. Autoimmune basis for visual paraneoplastic syndrome in patients with small-cell lung carcinoma. Lancet. 1985 Mar 23;1(8430):658–661. doi: 10.1016/s0140-6736(85)91326-1. [DOI] [PubMed] [Google Scholar]
  3. Jacobson D. M., Thirkill C. E., Tipping S. J. A clinical triad to diagnose paraneoplastic retinopathy. Ann Neurol. 1990 Aug;28(2):162–167. doi: 10.1002/ana.410280208. [DOI] [PubMed] [Google Scholar]
  4. Keltner J. L., Roth A. M., Chang R. S. Photoreceptor degeneration. Possible autoimmune disorder. Arch Ophthalmol. 1983 Apr;101(4):564–569. doi: 10.1001/archopht.1983.01040010564006. [DOI] [PubMed] [Google Scholar]
  5. Keltner J. L., Thirkill C. E., Tyler N. K., Roth A. M. Management and monitoring of cancer-associated retinopathy. Arch Ophthalmol. 1992 Jan;110(1):48–53. doi: 10.1001/archopht.1992.01080130050025. [DOI] [PubMed] [Google Scholar]
  6. Kornguth S. E., Klein R., Appen R., Choate J. Occurrence of anti-retinal ganglion cell antibodies in patients with small cell carcinoma of the lung. Cancer. 1982 Oct 1;50(7):1289–1293. doi: 10.1002/1097-0142(19821001)50:7<1289::aid-cncr2820500711>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  7. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  8. Sawyer R. A., Selhorst J. B., Zimmerman L. E., Hoyt W. F. Blindness caused by photoreceptor degeneration as a remote effect of cancer. Am J Ophthalmol. 1976 May;81(5):606–613. doi: 10.1016/0002-9394(76)90125-2. [DOI] [PubMed] [Google Scholar]
  9. Thirkill C. E., FitzGerald P., Sergott R. C., Roth A. M., Tyler N. K., Keltner J. L. Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med. 1989 Dec 7;321(23):1589–1594. doi: 10.1056/NEJM198912073212307. [DOI] [PubMed] [Google Scholar]
  10. Thirkill C. E., Tait R. C., Tyler N. K., Roth A. M., Keltner J. L. The cancer-associated retinopathy antigen is a recoverin-like protein. Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2768–2772. [PubMed] [Google Scholar]

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