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. 2016 Oct;101(10):e397–e400. doi: 10.3324/haematol.2016.148106

Figure 2.

Figure 2.

Global knockout of calpain-1 ameliorates chronic pain in Townes sickle mice. (A) Mechanical hyperalgesia, (B) sensitivity to heat, (C) sensitivity to cold, (D) deep tissue hyperalgesia, and (E) body weight are shown. Mean age of each group of female mice in months ± SEM are AA: 5.58 ± 0.21 (n = 10); SS: 5.51 ± 0.35 (n = 10); SSCKO: 6.23 ± 0.1 (n = 10). Values on the graphs are mean ± SEM. Differences between groups were analyzed by one-way ANOVA with Bonferroni multiple comparison. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. PWF: paw withdrawal frequency; PWL: paw withdrawal latency; BW: body weight; AA: Townes control mice; SS: Townes sickle mice; SSCKO: calpain-1 knockout Townes sickle mice.