Figure 3.

Effect of treatment on serum markers of bone turnover during treatment and follow-up. (A) The level of the bone formation marker N-terminal propeptide of procollagen I (P1NP) decreased from baseline to the interim assessment and then increased to the highest level at the end of treatment. After treatment completion a decrease was seen. (B) The highest level of the bone resorption marker C-terminal telopeptide (CTX) was seen at baseline with a rapid drop after initiation of treatment. None of the three patients with sustained high serum levels of CTX received treatment with bisphosphonates. EoT: end of treatment; FU1, 2 and 3: follow-up assessments 6, 12 and 18 months after the end of treatment. * = P<0.05, ** = P<0.01, *** = P<0.001.