Figure 3.

Depiction of the structure of the LINC (linker of nucleoskeleton and cytoskeleton) complex that bridges the cytoskeleton and nucleoskeleton. The complex comprises nesprin proteins (“KASH proteins”) in the outer nuclear membrane (ONM) and SUN proteins in the inner nuclear membrane (INM). Extending into the cytoplasm are extensions of the nesprins that are of variable size and interact with different cytoskeletal elements. The SUN proteins anchor the LINC complex to the nucleoskeleton through their nucleoplasmic domains by means of interaction with the nuclear lamina, as well as with chromosome-binding proteins and probably other anchoring proteins. (Reprinted from Chang et al. 2015.)