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Amyloid formation by the p53 DNA-binding domain (DBD). (A) Model of the p53 252-256 amyloid fibril generated based on molecular dynamics (MDs) simulations of the aggregation-prone sequence. (B) The DBD structure of p53 (PDB ID: 2XWR) (Natan et al. 2011) showing the amyloidogenic 251-258 region (red), Trp91/Arg174 (atomic detail), and equivalent sequence comparison.
