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Stress-activated MAPK-signaling pathways. The p38 MAP kinases are primarily activated by the MAPKK isoforms MKK3 and MKK6, but a minor contribution of MKK4 can be detected. All p38 MAPK isoforms are activated by MKK3 and MKK6, although p38δ is activated by MKK3 significantly more potently than MKK6. The JNK group of MAPKs is activated by the MAPKK isoforms MKK4 and MKK7.
