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. Author manuscript; available in PMC: 2017 Sep 27.
Published in final edited form as: Biochemistry. 2016 Sep 15;55(38):5423–5433. doi: 10.1021/acs.biochem.6b00735

Scheme 2.

Scheme 2

Synthesis of Substrate Analoguesa

aReagents and conditions: (a) Pd(PPh3)4, K2CO3/DME, H2O, 150 °C; (b) MeOH, K2HPO4(aq) (pH 6.5), 60 °C; (c) SOCl2/EtOH, 40 °C; (d) Ca(BH4)2/EtOH, −20 °C.