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Shift in the nicotinamide ring upon substrate binding. In the NADP+-bound Irp3 structure (light gray cartoon), the nicotinamide (light green sticks) is ring stacked with phenylalanine 17 (pink sticks). However, in the holo structure (dark gray cartoon), the nicotinamide of the NADP+ (dark green sticks) rotates away from phenylalanine (blue sticks) to align over the third ring in the substrate analogue (pale cyan sticks).
