Skip to main content
. Author manuscript; available in PMC: 2017 Sep 27.
Published in final edited form as: Biochemistry. 2016 Sep 15;55(38):5423–5433. doi: 10.1021/acs.biochem.6b00735

Figure 5.

Figure 5

Stereoview of active site tunnel. A tunnel from the surface of Irp3 (mesh) leads to the active site cavity (note red arrow). NADP+ is shown as green sticks, HPTT-COOH as pale cyan sticks, and tyrosine 128 as blue sticks. The M′–N′ loop (from the opposing monomer) is colored purple. The substrate is attached to an NRPS carrier domain through a phosphopantetheinyl tether that would be >20 Å long, allowing access to the active site via the tunnel. The surface topology was calculated using CASTp.46