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. 2016 Oct 3;4:20. doi: 10.1186/s40170-016-0159-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Identification of a Wnt responsive region in the SLC16A1 promoter region. A schematic (a) representing the ChIP peak region (486 nt) occupied by dnTCF-1, which was subcloned 5′ of the heterologous thymidine kinase (TK) core promoter and luciferase open reading frame. Luciferase reporter activity in SW480 (b), SW620 (c), HCT116 (d), and DLD1 (e) cells shows that the ChIP peak region confers elevated transcription activity to the heterologous TK promoter. The expression of transfected dnLEF-1, or treatment with the Wnt inhibitor XAV939 (10 μM) reduces the regulatory activity of these fragments. Graphs shown represent the average of three independent replicates (+/− SEM) (*p value < 0.05; **p value < 0.01; ***p value < 0.001)