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. 2016 Oct;41(10):623-627, 632-634.

Table 2.

Selected Treatments for PTSD in Veterans

First-Line Second-Line Alternative Pathways
Nonpharmacological29,38–47
  • Cognitive behavioral therapy
    • ○ Cognitive processing therapy
    • ○ Prolonged exposure therapy

  • Eye-movement desensitization and reprocessing
Pharmacological48–60
  • Antidepressants
    • ○ Sertraline*
    • ○ Paroxetine*
    • ○ Fluoxetine
    • ○ Venlafaxine

  • Nefazodone

  • Mirtazapine

  • Tricyclic antidepressants (e.g., imipramine)

  • Monoamine oxidase inhibitors (e.g., phenelzine)

  • Prazosin

  • Gamma-aminobutyric acid

  • Glutamate

  • Vortioxetine

  • Vilazodone

  • Anticonvulsants (e.g., topiramate)

  • Antiepileptics

  • Cannabis

PTSD = post-traumatic stress disorder.

*

These are the only drugs approved to treat PTSD by the Food and Drug Administration.