Table 1. Patient Characteristics and Univariable Association with pCR.
| Variable | Total (n=229) |
Non-pCR (n=170) |
pCR (n=59) |
p-value |
|---|---|---|---|---|
| Age at Diagnosis | 56 (21 - 87) | 56.5 (21 - 87) | 55 (32 - 80) | 0.499 |
| Sex | ||||
| Female | 94 (41) | 68 (72) | 26 (28) | 0.646 |
| Male | 135 (59) | 102 (76) | 33 (24) | |
| Race | ||||
| Asian | 13 (6) | 9 (69) | 4 (31) | 0.190 |
| Black | 9 (4) | 4 (44) | 5 (56) | |
| White | 192 (84) | 145 (76) | 47 (24) | |
| Unknown | 15 (7) | 12 (80) | 3 (20) | |
| Clinical Stage | ||||
| II | 52 (23) | 40 (77) | 12 (23) | 0.719 |
| III | 177 (77) | 130 (73) | 47 (27) | |
| Time between CRT and Surgery | ||||
| < 8 Weeks | 65 (28) | 53 (82) | 12 (18) | 0.133 |
| 8+ Weeks | 164 (72) | 117 (71) | 47 (29) | |
| Cycles of FOLFOX | ||||
| < 3 cycles | 135 (59) | 103 (76) | 32 (24) | 0.443 |
| 3+ cycles | 94 (41) | 67 (71) | 27 (29) | |
| KRAS | ||||
| Wild-type | 133 (58) | 88 (66) | 45 (34) | 0.001 |
| Mutant | 96 (42) | 82 (85) | 14 (15) | |
| TP53 | ||||
| Wild-type | 79 (34) | 58 (73) | 21 (27) | 0.874 |
| Mutant | 150 (66) | 112 (75) | 38 (25) | |
| KRAS and TP53 | ||||
| Not double-mutant | 170 (74) | 117 (69) | 53 (31) | 0.001 |
| Double mutant | 59 (26) | 53 (90) | 6 (10) |
Median (range) are presented for continuous variables, count (percentage) for categorical variables. Testing of patient characteristics between those with pCR and without pCR uses Fisher’s test for categorical variables and Wilcoxon rank sum test for continuous variables. pCR – pathologic complete response.