Table 1. Insulin Dose Algorithm.

Mean pre-breakfast glucose value and/or mean pre-dinner glucose value (mg/dL)	Adjustment of basal insulin or mixed insulin dose (units)
≤ 56	-4
56 - 80	-2
81 - 110	No adjustment
111 - 126	1
127 - 144	2
145 - 162	3
≥ 163	≥ 4

Bolus insulin dose adjusted at discretion of treating physician only if no episodes of severe hypoglycemia. Outpatient visits every 2 weeks for first few months in the insulin + tofogliflozin group and glargine + tofogliflozin group.