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. 2016 Oct 3;20:303. doi: 10.1186/s13054-016-1467-2

Table 2.

Proposed criteria for choosing between pharmacological and non-pharmacological antipyretic methods

Antipyretic agents Physical cooling
• Non sedated patients
• Concomitant need for analgesia
• Hypothalamic dysfunction
• Need for rapid induction
• Need for strict temperature control
• Patients with hemodynamic instability
• Failure of antipyretic agents