Table 4.

Pharmacokinetic Parameters Obtained from Plasma Samples of Patients Receiving Daily Oral Dose of Palbociclib on Day 15 of Cycle 2.

	Tmax (h)	Ctrough (ng/mL)	Cmax (ng/mL)	Dose-normalized Cmax (ng/mL)	AUC0-24h (h ng/mL)	Dose-normalized AUC0-24h (h ng/mL)
100 mg daily dose cohort (n=2)
Subject 002	8	49.4	70	70	1,476	1,476
Subject 003	8	65.2	101	101	2,012	2,012
Summary	8	56.8	84	84	1,723	1,723
125 mg daily dose cohort (n=4)
Subject 004	4	83.2	141	113	2,679	2,142
Subject 005	4	76.8	144	115	2,724	2,179
Subject 006	8	52.1	145	116	2,231	1,785
Subject 009	4	55.6	107	86	1,792	1,434
Summary	4 (4-8)	66 (23)	133 (14)	106 (14)	2,324 (19)	1,859 (19)

Data are median (range) for T_max and geometric mean (coefficient of variation%, CV%) for C_max, AUC_0-24h and dose-normalized AUC_0-24h