Fig. S4.

Data are from iPSC human dataset in B. (A) Frequency of replicons in each cohort, defined according to the following size ranges: <10³ bp, XS; 10³ to 10⁴ bp, S; 10⁴ to 10⁵ bp, M; 10⁵ to 10⁶ bp, L; and >10⁶ bp, XL. (B) Probability of DFS in each cohort of the replicons. (C) Higher-resolution plot of probability of DFS at the transition from M to L gap cohorts contributing most toward the P(DFS); red bars show the bins with maximum P(DFS) in respective datasets. (D) Theoretical frequency distribution of replicons inferred from C are presented in blue; gray shows the actual frequency distribution in those bins in the data, and red highlights the red bins in C.