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. 2016 Sep 27;4:e2348. doi: 10.7717/peerj.2348

Figure 8. The parametric Bio Linear Hybrid Automaton (Bio-LHA) of the significant cycle (0, 1, 0, 0, 0, 0, 0, 1, 0) → (0, 1, 0, 0, 1, 0, 0, 1, 0) → (0, 1, 0, 0, 1, 1, 0, 1, 0) → (0, 1, 0, 0, 0, 1, 0, 1, 0) → (0, 1, 0, 0, 0, 0, 0, 1, 0).

Figure 8

The states are represented by a vector containing expression level of genes in the order: NfκB, P21, FoXM1, Mdm2, OGT, OGA, C-Myc. The significant cycle is characterized by low expression of OGT and oncogenes, and oscillatory behavior of the p53-Mdm2 circuit resulting in homeostasis. Here, each location represents a qualitative state of the cycle with invariants (conjunction of constraints) and clock rates. The transitions are labeled with guards and the clock resets of evolving entities. The initial state (0,0,0,0,0,0,0,0,0) is represented by a small arrow shown in upper left corner.