Table 1. Values of logical parameters estimated by using SMBioNet.
The first column (Sr) indicates the serial number of each parameter with respect to its order of appearance in the SMBioNet input file (Supplemental Information 1). Each parameter is listed along with resources and permissible expression levels in second, third and fourth column, respectively. The fifth column (Selected) shows final values of logical parameters, computed by using SMBioNet.
| Sr. | Parameter | Resource | Range | Selected | Sr. | Parameter | Resource | Range | Selected |
|---|---|---|---|---|---|---|---|---|---|
| 1 | KNFκB | {} | [0] | 0 | 21 | KP21 | {p53} | [0-1] | 0 |
| 2 | KNFκB | {P21} | [0-1] | 0 | 22 | KP21 | {PI3K} | [0-1] | 0 |
| 3 | KNFκB | {PI3K} | [0-1] | 0 | 23 | KP21 | {FoxM1,p53} | [0-1] | 1 |
| 4 | KNFκB | {P21,PI3K} | [1] | 1 | 24 | KP21 | {p53,PI3K} | [0-1] | 1 |
| 5 | KPI3K | {} | [0] | 0 | 25 | KP21 | {FoxM1,PI3K} | [0-1] | 1 |
| 6 | KPI3K | {NFκB} | [0-1] | 0 | 26 | KP21 | {FoxM1,p53,PI3K} | [0-1] | 1 |
| 7 | KPI3K | {OGT} | [0-1] | 1 | 27 | KFoxM1 | {} | [0] | 0 |
| 8 | KPI3K | {p53} | [0-1] | 0 | 28 | KFoxM1 | {p53} | [0-1] | 0 |
| 9 | KPI3K | {NFκB,OGT} | [0-1] | 1 | 29 | KFoxM1 | {PI3K} | [0-1] | 1 |
| 10 | KPI3K | {OGT,p53} | [0-1] | 1 | 30 | KFoxM1 | {p53,PI3K} | [1] | 1 |
| 11 | KPI3K | {NFκB,p53} | [0-1] | 1 | 31 | KOGT | {} | [0] | 0 |
| 12 | KPI3K | {NFκB,OGT,p53} | [1] | 1 | 32 | KOGT | {C-Myc} | [0-1] | 1 |
| 13 | KOGA | {} | [0] | 0 | 33 | KOGT | {OGA} | [0-1] | 0 |
| 14 | KOGA | {OGT} | [1] | 1 | 34 | KOGT | {C-Myc,OGA} | [1] | 1 |
| 15 | Kp53 | {} | [0] | 0 | 35 | KMdm2 | {} | [0] | 0 |
| 16 | Kp53 | {Mdm2} | [0-1] | 1 | 36 | KMdm2 | {p53} | [1] | 1 |
| 17 | Kp53 | {NFκB} | [0-1] | 1 | 37 | KC-Myc | {} | [0] | 0 |
| 18 | Kp53 | {Mdm2,NFκB} | [0-1] | 1 | 38 | KC-Myc | {OGT} | [0-1] | 1 |
| 19 | KP21 | {} | [0] | 0 | 39 | KC-Myc | {p53} | [0-1] | 0 |
| 20 | KP21 | {FoxM1} | [0-1] | 0 | 40 | KC-Myc | {OGT,p53} | [1] | 1 |