. Author manuscript; available in PMC: 2016 Oct 3.

Published in final edited form as: Horm Metab Res. 2015 Sep 11;47(10):727–734. doi: 10.1055/s-0035-1559633

Table 1.

Characteristics of different TSH receptor antibodies.

	%TSH Block	Conformational/Linear	Function	Signaling effectors	Ref.
Stimulators
MS1 (Hamster)	80	±	Activation	cAMP/Akt/PKC/Ca ⁺	[13, 15, 20, 26]
RSR-12 (Mouse)	ND	±	Activation	cAMP/Akt/PKC/Ca ⁺	[22, 24, 26]
M22 (Human)	80	±	Activation	cAMP/Akt/PKC/Ca ⁺	[22, 24, 26]
Blockers
Tab-8 (Hamster)	80	±	TSH antagonist	No cAMP	[13, 15, 26]
RSR-B2 (Mouse)	80	±	Weak agonist	cAMP/ERK1/2	[26]
K1–70 (Human)	87	±	TSH antagonist	No cAMP	[28]
Cleavage
Tab-16 (Hamster) aa 322–341	0	±	Apoptosis	ROS	[13, 15, 20, 26]
7G10 (Hamster) aa 337–356	0	±	Apoptosis	ROS	[13, 15, 20, 26]