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. Author manuscript; available in PMC: 2016 Oct 3.
Published in final edited form as: Int J Gynecol Pathol. 2010 Mar;29(2):193–196. doi: 10.1097/PGP.0b013e3181b6a7d7

FIG. 1.

FIG. 1

(A) A low-power magnification of the vaginal biopsy hematoxylin and eosin section revealed a well-differentiated adenocarcinoma, and the overlying squamous mucosa showed high-grade vaginal intraepithelial neoplasia (10×). (B) The adenocarcinoma component consisted of back-to-back glands with slight nuclear atypia and few mitotic figures (40×). (C) The squamous mucosa overlying the adenocarcinoma shows a high-grade vaginal dysplasia in which the cells lacked normal maturation and reached the entire thickness of the squamous epithelium. Koilocytosis resulting from human papilloma virus effect are also present.