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. Author manuscript; available in PMC: 2016 Oct 3.
Published in final edited form as: Histopathology. 2011 Sep 21;59(5):1015–1018. doi: 10.1111/j.1365-2559.2011.03944.x

Figure 2.

Figure 2

Composite TEM micrograph of HEC1 Control cells (A,B), HecA1 4 h treated (C,D) and HEC1 24 h treated (E,F,) at magnifications of 4000 and 40 000 respectively. TEM of untreated HecA1 cells demonstrate rounded cells containing numerous mitochondria with occasional vacuoles (A) and on higher magnification demonstrate thin cisternae of rough endoplasmic reticulum and perinuclear pleomorphic electron dense mitochondria with intact cristae (B). These same cells at the 8 h time point show a greatly enlarged and highly vacuolated subcellular compartment at low magnification (C) and enlarged and swollen mitochondria with loss of cristae at the higher magnification (D). At the 24 h time point, cell death has occurred, which is evidenced by loss of integrity of the plasma membrane with resulting cell rupture (E). At higher magnification, most subcellular organelles are gone with only a few remnants of distended cisternae of rough endoplasmic reticulum and rare distorted mitochondria remaining (F).