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. 2016 Jun 16;3(3):ofw125. doi: 10.1093/ofid/ofw125

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© The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — New human immunodeficiency virus (HIV) infections prevented over 10 years of pre-exposure prophylaxis (PrEP) scale-up in primary base-case analysis. The PrEP coverage levels of 2.5%–15% are shown for unprioritized and age-prioritized PrEP. Optimistic (conservative) scenario assumptions were as follows: 90% (70%) PrEP efficacy vs wild-type HIV, 0%–50% relative efficacy vs rilpivirine-resistant HIV, 80% (70%) PrEP reliability, 40% (70%) cross-resistance between antiretroviral treatment and PrEP, and successful (all) PrEP injections select drug-resistant HIV after breakthrough infection.