Skip to main content
. 2016 Oct 3;11(10):e0164067. doi: 10.1371/journal.pone.0164067

Fig 1. Nine evolutionarily conserved metazoan FH2 domain subtypes.

Fig 1

The evolutionary history for 100 FH2 domain amino acid sequences from representatives of eleven metazoan phyla was inferred by the ML method for 343 amino acid positions occupied in ≥ 95% of sequences. All bootstrap values are indicated, and the scale bar indicates the number of substitutions per site for branch lengths. Nine groups populated by formins from multiple species clustered behind nodes with bootstrap values ≥ 50, suggesting the presence of nine evolutionarily conserved subtypes. Seven of these conformed to the previously recognized DAAM, DIAPH, FHOD, FMN, FMNL, INF and GRID2IP subtypes, while two others, designated MWHF and PHCF, were novel. Asterisks (*) indicate formins for which a partial FH2 domain sequence was used for this analysis.