Table 2.
Demographic and Disease Characteristics of Subjects with Deep Brain Stimulation.a Values reported are mean ± SD
| Variable | GBA (n = 11) | LRRK2 (n = 4) | PRKN (n = 10) | Nonmutation Carriers (n = 72) | P |
|---|---|---|---|---|---|
| Age of onset, y | 41.6 ± 5.3 | 47.5 ± 2.4 | 30.6 ± 9.1 | 41.2 ± 5.3 | <0.0001 |
| Age at baseline evaluation, y | 54.9 ± 2.6 | 64.3 ± 11.0 | 51.0 ± 10.6 | 57.4 ± 7.6 | 0.019 |
| Age at DBS implantation, y | 53.9 ± 2.6 (n = 9) | 60.8 ± 9.0 | 47.0 ± 11.5 | 55.2 ± 7.0 | 0.005 |
| Disease duration, y | 13.3 ± 4.9 | 16.8 ± 10.3 | 20.4 ± 7.3 | 16.1 ± 6.3 | 0.09 |
| AJ ancestry, % of subjects | 36.4 | 25.0 | 0.0 | 16.1 | 0.29 |
| UPDRS‐III score | 27.4 ± 14.5 | 30.8 ± 11.7 | 33.8 ± 20.5 (n = 6) | 23.4 ± 12.1 (n = 65) | 0.37 |
| MMSE score | 28.7 ± 1.3 | 28.3 ± 2.4 | 28.2 ± 1.8 | 28.6 ± 2.0 | 0.90 |
| Age of onset to DBS, ye | 10.9 ± 6.0 (n = 9) | 13.3 ± 8.5 | 16.4 ± 7.7 | 13.7 ± 5.7(n = 62) | 0.29 |
| DBS to current age, y | 1.6 ± 3.0 (n = 9) | 3.5 ± 2.4 | 4.0 ± 4.2 | 2.4 ± 2.6 (n = 62) | 0.28 |
| Prior report of dyskinesia, % of subjects | 100.0 (n = 6) | 66.6 (n = 3) | 80.0 (n = 8) | 75.4 (n = 61) | 0.55 |
a
One subject who carried both GBA and LRRK2 mutations was excluded.
SD, standard deviation; GBA, glucocerebrosidase; LRRK2, leucine‐rich repeat kinase 2; PKRN, parkin; DBS, deep brain stimulation; AJ, Ashkenazi Jewish; UPDRS‐III, the motor subsection of the Unified Parkinson's Disease Rating Scale; MMSE, Mini‐Mental Status Examination.