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. 2016 Oct 3;11(10):e0163919. doi: 10.1371/journal.pone.0163919

Fig 10. Effects of Amino acid permeases double mutant on in vivo virulence.

Fig 10

Representative photomicrographs of lungs, spleen, liver and brain from mice infected with H99, double mutant aap4Δ/aap5Δ and negative control (PBS), H&E stain. Histopathology analysis showed infection restricted to the lungs and increased inflammatory cell infiltration in double-mutant infected mice. Black arrows mark C. neoformans cells. In detail, arrowhead indicates budding yeast cell. Magnification: A, B, E, F, I, J x100; E, (in detail) x400; C, D, G, H, K, L x40.