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. 2016 Sep 15;129(18):3485–3498. doi: 10.1242/jcs.189860

Fig. 8.

Fig. 8.

Rab11b mediates TGF-β2-dependent KCC2 functional expression. (A) Somatodendritic Cl− gradients measured in cultured neurons (DIV10–15) transfected with Sh-Rab11b (n=6 independent experiments) and treated with TGF-β2. (B) Somatodendritic Cl− gradients measured in cultured neurons (DIV10-15) transfected with Sh-neg (n=5 independent experiments). Control cells (n=9) include those characterized in Fig. 4. (C) Quantification of EGABA gradient after TGF-β2 application. **P<0.01 compared to the controls, ##P<0.01 compared to Sh-Rab11b (unpaired Student's t-test). Statistical analysis for the cells transfected with Sh-Rab11b includes only those experiments where the ‘external control’ was positive, i.e. non-transfected cells from the same coverslip showed a clear difference in somatic and dendritic ECl−. Data are shown as mean±s.e.m. for the indicated number of experiments.