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K8/K18 IF modulation of PKCδ localization in lysosomes. Live-cell confocal imaging of PKCδ–EGFP in transfected WT and K8-null hepatocytes along with Lysotracker-labeled lysosomes, following treatment with PMA (100 nM), showing less PKCδ–EGFP and lysosome colocalization in hepatocytes lacking K8/K18 IFs. Yellow arrows point to colocalizations.
