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. 2016 Sep 29;9:5931–5941. doi: 10.2147/OTT.S106288

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© 2016 Markowitz et al. This work is published and licensed by Dove Medical Press Limited

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There is uniform clustering of microRNA (miRNA) expression in patients with similar cancer burden and receiving similar therapy.

Notes: (A) Chip 1 consisted of miRNA from eight patients undergoing treatment with interferon and bortezomib and four normal donor controls. For chip 1, only statistically significant miRNAs (P= 1/227=0.0043) are included in the heat map. (B) Chip 2 consisted of miRNA from seven melanoma patients receiving various treatments (surgery, radiation, immunotherapy, and/or targeted therapies) and four normal donor controls. (C) Chip 3 consisted of miRNAs from eight metastatic pancreatic cancer patients receiving various treatments (including gemcitabine-based, 5-fluorouracil-based, and participation in a clinical trial consisting of carboplatin/paclitaxel ± Reolysin virus and four normal donor controls). For chips 2 and 3, all miRNA with P<0.05 are included in the heat map given that fewer statistically significant miRNAs were found in these chips. Notice that even though there are fewer statistically significant individual miRNAs that are differentially expressed between the cancer patients and normal donor controls, the cancer groups still segregate fairly well as measured by the hierarchical clustering in the MeV program (www.tm4.org, Multi Experiment Viewer open source software).