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. 2016 Sep 29;11:2409–2417. doi: 10.2147/COPD.S105156

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© 2016 Pomerenke et al. This work is published and licensed by Dove Medical Press Limited

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Time course of cytokine mRNA expression in poly(I:C)- and R848-stimulated lung tissue.

Notes: The mRNA expression of TNFα (A and D), CCL5 (B and E), and IL-6 (C and F) in poly(I:C)- (100 μg/mL) (A–C) and R848-stimulated (10 μg/mL) (D–F) whole tissue explants from smokers and COPD patients (pooled, n=13) was measured after 1, 6, 24, and 48 hours. Data presented as median with range. ^{*, **, ***}Refer to significantly above time-matched unstimulated control (P<0.05, 0.01, 0.001, respectively). Horizontal line at y=1 represents unstimulated control. Results were obtained using a Wilcoxon matched-pairs test.

Abbreviations: TNFα, tumor necrosis factor α; IL-6, interleukin 6; COPD, chronic obstructive pulmonary disease; h, hour(s).