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DN-ROCK but not DN-PAK prevents the hypertonicity-induced phosphorylation of cof. Cells were transfected with Myc-tagged DN-ROCK (A) or DN-PAK1 (B) constructs, treated iso- or hypertonically, and stained for pcof (red) and the Myc epitope (green). *Identical cells on the red and green images. In A the contours of the transfected cell clusters are also shown. Note that DN-ROCK strongly reduces the hypertonically provoked rise in pcof labeling, whereas DN-PAK had no effect.
