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. 2016 Oct 4;7:171. doi: 10.3389/fgene.2016.00171

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Copyright © 2016 Yalamanchili, Kriete, Alfego, Danowski, Kari and Rodeck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of metabolic inhibitors on Bad and p53. (A) Increased Bad phosphorylation upon DNP/2DG treatment at concentrations of 5 mM each. The change is not significant. (B) Decreased p53 expression upon treatment with different inhibitors and concentrations. Results of densitometric analysis of immunoblots shown are normalized to the α-tubulin loading control. Means and standard deviations of three experiments are shown. The change is significant if compared to the control at concentrations of 5 nM DNP/5 mM 2DG and 10 μm FCCP/ 10 mM 2DG, (t-test, p < 0.001).