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. 2016 Jun 1;43(12):2139–2146. doi: 10.1007/s00259-016-3429-y

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Spatial reproducibility of the [¹⁸F]HX4 PET uptake in two patients with persistent hypoxia during treatment (left: patient with cT2N2aM0 hypopharynx cancer, right: patient with cT2N2bM0 oropharynx cancer. The PET-CT scans during treatment were in both patients performed after 18 Gy. Visualised is the voxel-wise correlation of the [¹⁸F]HX4-uptake within the GTV