Fig. 4.

The effect of acute (a) or chronic (b) administration of 1MeTIQ on 1BnTIQ-induced changes in dopamine release in the rat striatum, 1BnTIQ was administered chronically (1BnTIQch) at a dose of 25 mg/kg i.p. for 14 consecutive days. In the mixed group, 1MeTIQ (50 mg/kg i.p.) was given acutely (1MeTIQa) a 20 min before the last 1BnTIQ administration or chronically (1MeTIQch), b 20 min before each 1BnTIQ administration. The control group was treated with saline. The dialysate was collected every 20 min. The concentration of dopamine (DA) was measured. The data are expressed as the mean ± SEM (n = 5–6). Statistical significance: *p < 0.05, **p < 0.01 from the basal value; ⁺ p < 0.05 versus 1BnTIQ-treated group (Duncan’s test)